![]() ![]() Subtypes of calcium channels (e.g., Ca V1.2 and Ca V1.3 L-typeĬhannels) may be achieved in the future by exploiting differences between channel We describe how selectivity for different Intractable pain, gives an indication that these channels represent excellent drug Peptide blocker of N-type (Ca V2.2) calcium channels, as a treatment of The limited use of intrathecal ziconotide, a Therapeutic target of the gabapentinoid drugs, which are of value in certainĮpilepsies and chronic neuropathic pain. Target of ethosuximide, widely used in absence epilepsy. ![]() ![]() Widely used in the treatment of hypertension. Current therapeutic agents include drugs targeting L-typeĬa V1.2 calcium channels, particularly 1,4-dihydropyridines, which are Uses of drugs interacting with the different calcium channel subtypes and subunits,Īs well as specific areas in which there is strong potential for future drugĭevelopment. This review, the different subtypes of voltage-gated calcium channels are describedĪnd their physiologic roles and pharmacology are outlined. Voltage-gated calcium channels are required for many key functions in the body. ![]()
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